# Lawrence 1993: Detecting Subtle Sequence Signals: a Gibbs Sampling Strategy for Multiple Alignment

> Charles E. Lawrence, Stephen F. Altschul, Mark S. Boguski et al., 1993. 1 records on Mysteries Department cite it. Listed in the citation index of the…

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# Detecting Subtle Sequence Signals: a Gibbs Sampling Strategy for Multiple Alignment

Charles E. Lawrence, Stephen F. Altschul, Mark S. Boguski et al., 1993. _Science_.

Introduces a Gibbs sampling algorithm that finds short shared patterns across many protein or DNA sequences by local multiple alignment.

**Voynich Manuscript** Articledoi: **[10.1126/science.8211139](https://doi.org/10.1126/science.8211139)** Checked against the original0

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Listed in the citation index of the bioinformatics and signal-analysis survey.

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## Cite it

```
Lawrence, C. E., Altschul, S. F., Boguski, M. S., Liu, J. S., Neuwald, A. F., & Wootton, J. C. (1993). Detecting Subtle Sequence Signals: a Gibbs Sampling Strategy for Multiple Alignment. Science. https://doi.org/10.1126/science.8211139
```

[Find it at doi.org](https://doi.org/10.1126/science.8211139)

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